La Jolla, California

artefille-image-galleryDiscover an innovation in safe, enduring, wrinkle correction. When you are ready to experience results that stay, Artefill is the choice.

Experienced filler patients, and those who simply don’t want to deal with repeat injections will find this unique two-part filler provides both instant effect and continuing effect for years to come.

Dr. Mani is a Diamond Elite provider for Artefill. As a Regional Artefill training physician, her extensive experience levels ensure safe and effective results.

“Dear Dr. Mani,

I am so grateful I picked you as my doctor! … I can say the results were amazing. I feel not only like I look a good 10 years younger but no longer dread waking up in the morning and facing the mirror. I cannot tell how this procedure has had such an affect on my whole outlook towards life. Feeling good about how I look has helped my career and my relationships with others. I feel empowered again.

Thanks so much!” Cindy Rehnberg

Artefill is an in-office procedure that answers the demand for immediate, enduring wrinkle correction. ArteFill is the first and only FDA-approved which contains 20% non-resorbable, permanently placed microspheres.  In our clinic we use Artefill for Nasolabial Folds, Volume Deficiency and Volume Loss, Under Eye Hollows, Indented Scars and Facial Deformities.


What is Artefill?


Artefill at this time is the only FDA-approved non-resorbable filler for the correction of facial folds and smile lines. Non-resorbable means there are components that do not degrade and stay in the skin permanently. Artefill consists of 20% PMMA and 80% purified bovine collagen gel. There is added 0.3% lidocaine which provides anesthetic benefit for injection comfort.

How does Artefill work?

The collagen in Artefill provides an immediate correction where placed. The PMMA microspheres provide a long lasting support structure. As the bovine collagen degrades, your own collagen takes its place and interweaves around the PMMA, providing the long lasting effects.

Why choose Artefill over other fillers?

Facial wrinkles are a result of the natural aging process. Over time, the skin loses its ability to repair itself as the underlying elastin and collagen fibers break down and lose elasticity. Heredity, UV exposure, and repetitive facial movement can all contribute to the development of facial wrinkles and folds and under eye hollowing. Studies have shown that ArteFill is a highly differentiated and unique product, one which is both safe as well as an effective treatment for patients. ArteFill gives patients who seek long-lasting wrinkle corrections a new option.

What are Artefill’s Benefits?

  • Immediate correction
  • Correction that can last years instead of only months
  • Simple injection with proven safety profile for properly selected patients
  • Typically requires only 1 or 2 treatments
  • Option of ArteFill Progressive Enhancement™: a process of gradual correction through lesser volume treatments so you get exactly the volume of correction you desire

Is ArteFill injected differently than other fillers?

Artefill is injected very similarly as other fillers, but somewhat deeper. The ideal placement is directly above the fat layer so there is deep layer support. We now offer the option of microcannula injection which reduces the use of needles, replacing them with smooth tipped flexible cannulas for extra comfort and reduced bruising.

What are the potential side effects?

As with any injected product, you may experience bruising and/or slight swelling. **To lessen bruising, stop taking aspirin, anti-inflammatories and supplements two weeks prior if possible. If you take Rx blood thinners, you must talk with your primary physician first to see if it is safe for you to seek cosmetic injections or laser treatments.  See supplements to avoid to help lessen bruising. Some seemingly innocent supplements can cause big problems!

How is Artefill different from temporary dermal fillers?

Temporary fillers are broken down over time by the body’s reaction to a foreign substance. They are made to do this. Artefill has the inert microbeads which do no not break down. This is what provides the ongoing support for your own collagen modification. For those who are more comfortable with the idea of a less permanent choice or wish to have filler products for the lip or finer lines, the alternatives include Juvederm – a hyaluronic acid gel which is an ideal product for plumping the lips; Radiesse for nasolabial folds (longevity around 18 months) and for injectable augmentation of the cheeks or chin; Restylane for a variety of wrinkle and line correction; and Belotero for fine lines around the mouth and lips. A newer product, Juvederm Voluma, offers a midface volume replacement that studies show lasts up to 2 years.

Related Wrinkle and Facial Fold Treatments

If you would like to learn more about what La Jolla Cosmetic Laser Clinic has to offer, please contact us to make an appointment.

Nasrin Mani, MD is the founder of La Jolla Cosmetic Laser Clinic and one of the area’s few regional trainers for Artefill.

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